Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes

Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.

The down-regulation or cellular depletion of protein kinase C (PKC) attendant to prolonged activation by phorbol esters is a widely described property of this key family of signaling enzymes. However, neither the mechanism of down-regulation nor whether this mechanism occurs following stimulation by physiological agonists is known. Here we show that the peptidyl-prolyl isomerase Pin1 provides a...

The Peptidyl-Prolyl Isomerase Pin1 Regulates

The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.

Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout mouse embryonic fibroblasts show a cytokinesis delay, and depletion of Pin1 f...

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

RATIONALE Cardiac hypertrophy results from the complex interplay of differentially regulated cascades based on the phosphorylation status of involved signaling molecules. Although numerous critical regulatory kinases and phosphatases have been identified in the myocardium, the intracellular mechanism for temporal regulation of signaling duration and intensity remains obscure. In the nonmyocyte ...

Regulation of Bruton’s tyrosine kinase (Btk) by the peptidyl-rolyl isomerase Pin1

Regulation of Bruton’s tyrosine kinase (Btk) by the peptidyl-rolyl isomerase Pin1 Liang Yu, Abdalla J. Mohamed,* Leonardo Vargas, Anna Berglöf, Greg Finn, Kun Ping Lu, and C. I. Edvard Smith* Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, SE-4186, Stockholm, Sweden. Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel ...